Ontology highlight
ABSTRACT:
SUBMITTER: Tomasi M
PROVIDER: S-EPMC8619961 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Tomasi Michele M Dalsass Mattia M Beghini Francesco F Zanella Ilaria I Caproni Elena E Fantappiè Laura L Gagliardi Assunta A Irene Carmela C König Enrico E Frattini Luca L Masetti Giulia G Isaac Samine Jessica SJ Armanini Federica F Cumbo Fabio F Blanco-Míguez Aitor A Grandi Alberto A Segata Nicola N Grandi Guido G
Vaccines 20211118 11
A large body of data both in animals and humans demonstrates that the gut microbiome plays a fundamental role in cancer immunity and in determining the efficacy of cancer immunotherapy. In this work, we have investigated whether and to what extent the gut microbiome can influence the antitumor activity of neo-epitope-based cancer vaccines in a BALB/c-CT26 cancer mouse model. Similarly to that observed in the C57BL/6-B16 model, <i>Bifidobacterium</i> administration per se has a beneficial effect ...[more]