Ontology highlight
ABSTRACT:
SUBMITTER: Brewer CM
PROVIDER: S-EPMC8623355 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Brewer Chris M CM Nelson Branden R BR Wakenight Paul P Collins Sarah J SJ Okamura Daryl M DM Dong Xiu Rong XR Mahoney William M WM McKenna Aaron A Shendure Jay J Timms Andrew A Millen Kathleen J KJ Majesky Mark W MW
Developmental cell 20211004 19
Spiny mice (Acomys cahirinus) are terrestrial mammals that evolved unique scar-free regenerative wound-healing properties. Myofibroblasts (MFs) are the major scar-forming cell type in skin. We found that following traumatic injury to ear pinnae, MFs appeared rapidly in both Acomys and mouse yet persisted only in mouse. The timing of MF loss in Acomys correlated with wound closure, blastema differentiation, and nuclear localization of the Hippo pathway target protein Yap. Experiments in vitro rev ...[more]