The transmission of drug-resistant strains of HIV in heterosexual populations based on genetic sequences.

ABSTRACT:

Background

China's National Free Antiretroviral Treatment Program (NFATP) has substantially reduced morbidity and HIV/AIDS incidence since 2003. However, HIV resistance to antiretroviral drugs (ARVs) has been a major challenge for the current treatment of HIV/AIDS in China.

Methods

In the current study, we established a nested dynamic model to predict the multi-drug resistance dynamics of HIV among the heterosexual population and evaluated the impact of intervention measures on the transmission of drug resistance. We obtained an effective reproductive number [Formula: see text] from each sub-model held at different stages of the dynamic model. Meanwhile, we applied Bayesian phylogenetic methods to infer the weighted average effective reproductive number [Formula: see text] f

SUBMITTER: Jin X 

PROVIDER: S-EPMC8635345 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature