Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC8642600 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Zhang Shenwu S Wang Yuequan Y Kong Zhiqiang Z Zhang Xuanbo X Sun Bingjun B Yu Han H Chen Qin Q Luo Cong C Sun Jin J He Zhonggui Z
Acta pharmaceutica Sinica. B 20210420 11
Pure drug-assembled nanomedicines (PDANs) are currently under intensive investigation as promising nanoplatforms for cancer therapy. However, poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical translation. Herein, we report a core-matched nanoassembly of pyropheophorbide a (PPa) for photodynamic therapy (PDT). Pure PPa molecules are found to self-assemble into nanoparticles (NPs), and an amphiphilic PEG polymer (PPa-PEG<sub>2K</s ...[more]