Ontology highlight
ABSTRACT:
SUBMITTER: Hasegawa H
PROVIDER: S-EPMC8658440 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Hasegawa Hijiri H Sasaki Ikkei I Tsukakoshi Kaori K Ma Yue Y Nagasawa Kazuo K Numata Shusuke S Inoue Yuuki Y Kim Yeji Y Ikebukuro Kazunori K
International journal of molecular sciences 20211206 23
Genomic DNA methylation is involved in many diseases and is expected to be a specific biomarker for even the pre-symptomatic diagnosis of many diseases. Thus, a rapid and inexpensive detection method is required for disease diagnosis. We have previously reported that cytosine methylation in G-quadruplex (G4)-forming oligonucleotides develops different G4 topologies. In this study, we developed a method for detecting CpG methylation in G4-forming oligonucleotides based on the structural differenc ...[more]