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TGF-β Signaling and Resistance to Cancer Therapy.

ABSTRACT: The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition and invasion in advanced cancer, is considered to act as a double-edged sword in cancer. Multiple inhibitors have been developed to target TGF-β signaling, but results from clinical trials were inconsistent, suggesting that the functions of TGF-β in human cancers are not yet fully explored. Multiple drug resistance is a major challenge in cancer therapy; emerging evidence indicates that TGF-β signaling may be a key factor in cancer resistance to chemotherapy, targeted therapy and immunotherapy. Finally, combining anti-TGF-β therapy with other cancer therapy is an attractive venue to be explored for the treatment of therapy-resistant cancer.

SUBMITTER: Zhang M

PROVIDER: S-EPMC8669610 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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TGF-β Signaling and Resistance to Cancer Therapy.

Zhang Maoduo M Zhang Ying Yi YY Chen Yongze Y Wang Jia J Wang Qiang Q Lu Hezhe H

Frontiers in cell and developmental biology 20211130

The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition and invasion in advanced cancer, is considered to act as a double-edged sword in cancer. Multiple inhibitors have been developed to target TGF-β signaling, but results from clinical trials were inconsistent, suggesting that the functions of TGF-β in human cancers are not yet fully explored. Multipl ...[more]

PMID: 34917620

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