Ontology highlight
ABSTRACT:
SUBMITTER: Ban Y
PROVIDER: S-EPMC8670735 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Nature cancer 20210920 9
Radiation therapy (RT) in combination with immune checkpoint inhibitor (ICI) represents a promising regimen for non-small cell lung cancer (NSCLC), however, the underlying mechanisms are poorly characterized. We identified a specific dose of RT that conferred tumor regression and improved survival in NSCLC models when combined with ICI. The immune-modulating functions of RT was ascribed to activated lung-resident Scgb1a1+ club cells. Importantly, mice with club cell-specific knockout of synaptos ...[more]