Ontology highlight
ABSTRACT:
SUBMITTER: Ji Y
PROVIDER: S-EPMC8699704 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Ji Yuanyuan Y Koch Dennis D González Delgado Jule J Günther Madlen M Witte Otto W OW Kessels Michael M MM Frahm Christiane C Qualmann Britta B
PLoS biology 20211213 12
Ischemic stroke is a major cause of death and long-term disability. We demonstrate that middle cerebral artery occlusion (MCAO) in mice leads to a strong decline in dendritic arborization of penumbral neurons. These defects were subsequently repaired by an ipsilateral recovery process requiring the actin nucleator Cobl. Ischemic stroke and excitotoxicity, caused by calpain-mediated proteolysis, significantly reduced Cobl levels. In an apparently unique manner among excitotoxicity-affected protei ...[more]