Frailty-Independent Undertreatment Negative Impact on Survival in Older Patients With Breast Cancer.

ABSTRACT:

Purpose

The management of older adults with breast cancer (BC) remains controversial. The challenging assessment of aging idiosyncrasies and the scarce evidence of therapeutic guidelines can lead to undertreatment. Our goal was to measure undertreatment and assess its impact on survival.

Methods

Consecutive patients with BC aged 70 years or older were prospectively enrolled in 2014. Three frailty screening tools (G8, fTRST, and GFI) and two functional status scales (Karnofsky performance score and Eastern Cooperative Oncology Group Performance Status) were applied. Disease characteristics, treatment options, and causes of mortality were recorded during a 5-year follow-up. In addition, we defined undertreatment and correlated its survival impact with frailty.

Results

A

SUBMITTER: Osorio F 

PROVIDER: S-EPMC8724373 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature