Real-time monitoring of drug pharmacokinetics within tumor tissue in live animals.
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ABSTRACT:
SUBMITTER: Seo JW
PROVIDER: S-EPMC8741190 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Real-time monitoring of drug pharmacokinetics within tumor tissue in live animals.
Seo Ji-Won JW Fu Kaiyu K Correa Santiago S Eisenstein Michael M Appel Eric A EA Soh Hyongsok T HT
Science advances 20220107 1
The efficacy and safety of a chemotherapy regimen fundamentally depends on its pharmacokinetics. This is currently measured based on blood samples, but the abnormal vasculature and physiological heterogeneity of the tumor microenvironment can produce radically different drug pharmacokinetics relative to the systemic circulation. We have developed an implantable microelectrode array sensor that can collect such tissue-based pharmacokinetic data by simultaneously measuring intratumoral pharmacokin ...[more]
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