RedChIP identifies noncoding RNAs associated with genomic sites occupied by Polycomb and CTCF proteins.
Ontology highlight
ABSTRACT:
SUBMITTER: Gavrilov AA
PROVIDER: S-EPMC8742611 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Nuclear noncoding RNAs are key regulators of gene expression and chromatin organization. Here we present RedChIP, a technique combining RNA-DNA proximity ligation and chromatin immunoprecipitation for identification of RNAs associated with genomic regions occupied by a protein of interest. We identify a spectrum of cis and trans acting lincRNAs enriched at Polycomb and CTCF binding sites, which may be involved in Polycomb mediated gene repression and chromatin looping.
2021-12-18 | GSE174474 | GEO
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