Pathobiology, irradiation dosimetric parameters and therapy of radiation-induced gastric damage: a narrative review.

ABSTRACT:

Objective

To review the pathobiology, irradiation dosimetric parameters and other risk factors, and therapy of radiation-induced gastric damage (RIGD).

Background

RIGD is a side-effect of upper abdominal radiotherapy. Acute toxicities are usually mild and self-limiting. Late toxicities are potentially life-threatening and include bleeding, perforation or stenosis. The data on RIGD is mainly historical and derived from neoplasms and treatments where the role of radiotherapy is contracting, such as para-aortic nodal irradiation for testis and cervical cancer and Hodgkin's Disease. On the other hand, the role of radiotherapy is expanding, especially with stereotactic body radiotherapy (SBRT) treatments evolving for both primary and secondary upper gastrointestinal neoplasms, wh

SUBMITTER: McKay MJ 

PROVIDER: S-EPMC8748060 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature