Ontology highlight
ABSTRACT:
SUBMITTER: Riccio F
PROVIDER: S-EPMC8748454 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Riccio Federica F Micarelli Elisa E Secci Riccardo R Giuliani Giulio G Vumbaca Simone S Massacci Giorgia G Castagnoli Luisa L Fuoco Claudia C Cesareni Gianni G
Cell death discovery 20220110 1
Repurposing of drugs for new therapeutic use has received considerable attention for its potential to limit time and cost of drug development. Here we present a new strategy to identify chemicals that are likely to promote a desired phenotype. We used data from the Connectivity Map (CMap) to produce a ranked list of drugs according to their potential to activate transcription factors that mediate myeloid differentiation of leukemic progenitor cells. To validate our strategy, we tested the in vit ...[more]