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Emerging rejuvenation strategies-Reducing the biological age.

ABSTRACT: Several interventions have recently emerged that were proposed to reverse rather than just attenuate aging, but the criteria for what it takes to achieve rejuvenation remain controversial. Distinguishing potential rejuvenation therapies from other longevity interventions, such as those that slow down aging, is challenging, and these anti-aging strategies are often referred to interchangeably. We suggest that the prerequisite for a rejuvenation intervention is a robust, sustained, and systemic reduction in biological age, which can be assessed by biomarkers of aging, such as epigenetic clocks. We discuss known and putative rejuvenation interventions and comparatively analyze them to explore underlying mechanisms.

SUBMITTER: Zhang B

PROVIDER: S-EPMC8761015 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Emerging rejuvenation strategies-Reducing the biological age.

Zhang Bohan B Trapp Alexandre A Kerepesi Csaba C Gladyshev Vadim N VN

Aging cell 20211231 1

Several interventions have recently emerged that were proposed to reverse rather than just attenuate aging, but the criteria for what it takes to achieve rejuvenation remain controversial. Distinguishing potential rejuvenation therapies from other longevity interventions, such as those that slow down aging, is challenging, and these anti-aging strategies are often referred to interchangeably. We suggest that the prerequisite for a rejuvenation intervention is a robust, sustained, and systemic re ...[more]

PMID: 34972247

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