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Dendriplex-Impregnated Hydrogels With Programmed Release Rate.

ABSTRACT: Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA-dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.

SUBMITTER: Apartsin E

PROVIDER: S-EPMC8766751 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Dendriplex-Impregnated Hydrogels With Programmed Release Rate.

Apartsin Evgeny E Venyaminova Alya A Majoral Jean-Pierre JP Caminade Anne-Marie AM

Frontiers in chemistry 20220105

Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA-dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biome ...[more]

PMID: 35071182

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