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Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis.

ABSTRACT:

Objective

Current findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis.

Methods

Eligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched in PubMed, Cochrane Library, CNRI, and VIP using keywords such as "MMP-9", "matrix metallopeptidase-9" and "myocardial infarction", "acute myocardial infarction", "AMI", and "polymorphism". Data from eligible literatures were extracted for calculating OR and corresponding 95% CI using RevMan 5.3 and STATA12.0.

Results

Ten independent literatures reporting MMP-9 rs3918242 and susceptibility to MI were enrolled. Compared with subjects carrying CT&TT genotype of MMP-9 rs3918242, susceptibility to MI was lower in those carrying CC genotype (OR = 1.49, 95%CI = 1.19-1.86, P = 0.0004). Such a significance was observed in the overdominant (OR = 1.27, 95%CI = 1.14-1.41, P < 0.0001) and allele genetic models (OR = 1.43, 95%CI = 1.17-1.74, P = 0.0005) as well. This finding was also valid in the Asian population.

Conclusions

Mutation on MMP-9 rs3918242 has a potential relevance with susceptibility to MI.

SUBMITTER: Feng B

PROVIDER: S-EPMC8783703 | biostudies-literature |

REPOSITORIES: biostudies-literature

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