Dataset Information

Reproductive and hormonal risk factors for sarcoidosis: a nested case-control study.

ABSTRACT:

Background

Sarcoidosis incidence peaks in females around the fifth decade of life, which coincides with menopause, suggesting hormonal factors play a role in disease development. We investigated whether longer exposure to reproductive and hormonal factors is associated with reduced sarcoidosis risk.

Methods

We conducted a matched case-control study nested within the Mammography Screening Project. Incident sarcoidosis cases were identified via medical records and matched to controls on birth and questionnaire date (1:4). Information on hormonal factors was obtained through questionnaires prior to sarcoidosis diagnosis. Multilevel modelling was used to estimate adjusted odds ratios with 95% credible intervals (OR; 95% CI).

Results

In total, 32 sarcoidosis cases and 124 controls were included. Higher sarcoidosis odds were associated with older age at menarche (OR 1.19: 95% CI 0.92-1.55), natural menopause versus non-natural (OR 1.53: 95% CI 0.80-2.93), later age at first pregnancy (OR 1.11: 95% CI 0.76-1.63) and ever hormone replacement therapy (HRT) use (OR 1.40: 95% CI 0.76-2.59). Lower odds were associated with older age at menopause (OR 0.90: 95% CI 0.52-1.55), longer duration of oral contraceptive use (OR 0.70: 95% CI 0.45-1.07), longer duration of HRT use (OR 0.61: 95% CI 0.22-1.70), ever local estrogen therapy (LET) use (OR 0.83: 95% CI 0.34-2.04) and longer duration of LET use (OR 0.78: 95% CI 0.21-2.81). However, the CIs could not rule out null associations.

Conclusion

Given the inconsistency and modest magnitude in our estimates, and that the 95% credible intervals included one, it still remains unclear whether longer estrogen exposure is associated with reduced sarcoidosis risk.

SUBMITTER: Dehara M

PROVIDER: S-EPMC8787880 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Publications

Reproductive and hormonal risk factors for sarcoidosis: a nested case-control study.

Dehara Marina M Sachs Michael C MC Kullberg Susanna S Grunewald Johan J Blomberg Anders A Arkema Elizabeth V EV

BMC pulmonary medicine 20220124 1

<h4>Background</h4>Sarcoidosis incidence peaks in females around the fifth decade of life, which coincides with menopause, suggesting hormonal factors play a role in disease development. We investigated whether longer exposure to reproductive and hormonal factors is associated with reduced sarcoidosis risk.<h4>Methods</h4>We conducted a matched case-control study nested within the Mammography Screening Project. Incident sarcoidosis cases were identified via medical records and matched to control ...[more]

PMID: 35073900

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Dataset Information

Reproductive and hormonal risk factors for sarcoidosis: a nested case-control study.

Background

Methods

Results

Conclusion

Publications

Reproductive and hormonal risk factors for sarcoidosis: a nested case-control study.

Similar Datasets

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