Menstrual, reproductive and hormonal factors and thyroid cancer: a hospital-based case-control study in China.
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ABSTRACT: Background
There have been considerable studies on the effects of reproductive factors on thyroid cancer risk, while findings are inconsistent. In this analysis, we aimed to investigate the associations between menstrual, reproductive and hormonal factors with thyroid cancer occurrence in a population of Chinese women.Methods
Using data from a 1:1 matched case-control study performed between 2015 and 2017 in Zhejiang Province of China, a second analysis of 2261 pairs of female subjects was conducted. The possible effects for thyroid cancer were evaluated in logistic regression models by odds ratios (ORs) with 95% confidence intervals (CIs).Results
Later age at first pregnancy (for?>?25 vs. ??20 years, OR: 0.47, 95% CI 0.23-0.96) and longer duration of breast feeding (for 6-12 vs. ??6 months, OR: 0.49, 95% CI 0.24-0.98) were significantly associated with decreased occurrence of thyroid cancer, while no trend was observed. Stratified by age at enrollment, only the association with duration of breast feeding remained significant, but limited to younger women (??50 years).Conclusions
Our results suggested that women with later age at first pregnancy or longer breast feeding duration were less likely to have thyroid cancer. These findings supported an influence role of reproductive factors in thyroid cancer risk.
SUBMITTER: Wang M
PROVIDER: S-EPMC7789638 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Menstrual, reproductive and hormonal factors and thyroid cancer: a hospital-based case-control study in China.
Wang Meng M Gong Wei-Wei WW He Qing-Fang QF Hu Ru-Ying RY Yu Min M
BMC women's health 20210106 1
<h4>Background</h4>There have been considerable studies on the effects of reproductive factors on thyroid cancer risk, while findings are inconsistent. In this analysis, we aimed to investigate the associations between menstrual, reproductive and hormonal factors with thyroid cancer occurrence in a population of Chinese women.<h4>Methods</h4>Using data from a 1:1 matched case-control study performed between 2015 and 2017 in Zhejiang Province of China, a second analysis of 2261 pairs of female su ...[more]
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