Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns.

ABSTRACT: The production of personalized cancer vaccines made from autologous tumour cells could benefit from mechanisms that enhance immunogenicity. Here we show that cancer vaccines can be made via the cryogenic silicification of tumour cells, which preserves tumour antigens within nanoscopic layers of silica, followed by the decoration of the silicified surface with pathogen-associated molecular patterns. These pathogen-mimicking cells activate dendritic cells and enhance the internalization, processing and presentation of tumour antigens to T cells. In syngeneic mice with high-grade ovarian cancer, a cell-line-based silicified cancer vaccine supported the polarization of CD4⁺ T cells towards the T-helper-1 phenotype in the tumour microenvironment, and induced tumour-antigen-specific T

SUBMITTER: Guo J 

PROVIDER: S-EPMC8792180 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature