Ontology highlight
ABSTRACT:
SUBMITTER: Bondarenko V
PROVIDER: S-EPMC8831596 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Bondarenko Vasyl V Wells Marta M MM Chen Qiang Q Tillman Tommy S TS Singewald Kevin K Lawless Matthew J MJ Caporoso Joel J Brandon Nicole N Coleman Jonathan A JA Saxena Sunil S Lindahl Erik E Xu Yan Y Tang Pei P
Nature communications 20220210 1
The intracellular domain (ICD) of Cys-loop receptors mediates diverse functions. To date, no structure of a full-length ICD is available due to challenges stemming from its dynamic nature. Here, combining nuclear magnetic resonance (NMR) and electron spin resonance experiments with Rosetta computations, we determine full-length ICD structures of the human α7 nicotinic acetylcholine receptor in a resting state. We show that ~57% of the ICD residues are in highly flexible regions, primarily in a l ...[more]