Ontology highlight
ABSTRACT:
SUBMITTER: Prague M
PROVIDER: S-EPMC8846636 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Prague Mélanie M Lavielle Marc M
CPT: pharmacometrics & systems pharmacology 20220201 2
The success of correctly identifying all the components of a nonlinear mixed-effects model is far from straightforward: it is a question of finding the best structural model, determining the type of relationship between covariates and individual parameters, detecting possible correlations between random effects, or also modeling residual errors. We present the Stochastic Approximation for Model Building Algorithm (SAMBA) procedure and show how this algorithm can be used to speed up this process ...[more]