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Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses.

ABSTRACT: The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome, and phosphoproteome. We showed the ebb and flow of several host responses in the lung across the viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. This multiplex evaluation also revealed that many kinases of the CDK and MAPK family were interactive and served as functional hubs in mediating the signal transduction during SARS-CoV-2 infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies.

SUBMITTER: Wang ZN

PROVIDER: S-EPMC8863311 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses

Project description:Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome and phosphoproteome. We showed the ebb and flow of several host responses in the lung across viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies.

2022-03-01 | GSE196488 | GEO

Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses

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Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses

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Absence of host innate immune responses in SARS-CoV-infected ferrets upon subsequent challenge

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