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Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses

ABSTRACT: Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses

PROVIDER: PRJNA805187 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17972654_1.fastq.gz	Fastqsanger.gz
	SRR17972654_2.fastq.gz	Fastqsanger.gz
	SRR17972655_1.fastq.gz	Fastqsanger.gz
	SRR17972655_2.fastq.gz	Fastqsanger.gz
	SRR17972656_1.fastq.gz	Fastqsanger.gz

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Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses

Project description:Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome and phosphoproteome. We showed the ebb and flow of several host responses in the lung across viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies.

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