Dataset Information

Maternal occupational physical activity and risk for orofacial clefts.

ABSTRACT:

Objectives

To perform a case-control study of maternal occupational physical activity and risk for orofacial clefts in Texas during 1999-2009.

Methods

We used logistic regression to assess 14 measures of physical activity estimated from a job exposure matrix, using the maternal occupation reported on the birth certificate, among 887 children with cleft lip with or without cleft palate (CLP), 436 children with cleft palate only (CP), and 1932 controls.

Results

After adjusting for several potential confounders, seven measures of physical activity (as a categorical and/or continuous variable) were significantly associated with CLP, CP, or both. Positive associations were seen for keeping balance, kneeling, standing, and walking/running (odds ratio 95% confidence interval range 1.0-1.9 for fourth versus first quartile). A significant positive trend was also seen for bending/twisting. Negative associations were seen for repetitive motion and sitting.

Conclusions

Maternal occupational physical activity may be related to the etiology of orofacial clefts.

SUBMITTER: Agopian AJ

PROVIDER: S-EPMC8924980 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Publications

Maternal occupational physical activity and risk for orofacial clefts.

Agopian A J AJ Kim Jihye J Langlois Peter H PH Lee Laura L Whitehead Lawrence W LW Symanski Elaine E Herdt Michele L ML Delclos George L GL

American journal of industrial medicine 20170519 7

<h4>Objectives</h4>To perform a case-control study of maternal occupational physical activity and risk for orofacial clefts in Texas during 1999-2009.<h4>Methods</h4>We used logistic regression to assess 14 measures of physical activity estimated from a job exposure matrix, using the maternal occupation reported on the birth certificate, among 887 children with cleft lip with or without cleft palate (CLP), 436 children with cleft palate only (CP), and 1932 controls.<h4>Results</h4>After adjustin ...[more]

PMID: 28524264

Similar Datasets

Project description:BackgroundThe association between the risk of orofacial clefts in infants and the use of corticosteroids during pregnancy is unclear from the available evidence. We conducted a nationwide cohort study of all live births in Denmark over a 12-year period.MethodsWe collected data on all live births in Denmark from Jan. 1, 1996, to Sept. 30, 2008. We included live births for which information was available from nationwide health registries on the use of corticosteroids during pregnancy, the diagnosis of an orofacial cleft and possible confounders.ResultsThere were 832,636 live births during the study period. Exposure to corticosteroids during the first trimester occurred in 51,973 of the pregnancies. A total of 1232 isolated orofacial clefts (i.e., cleft lip, cleft palate, or cleft lip and cleft palate) were diagnosed within the first year of life, including 84 instances in which the infant had been exposed to corticosteroids during the first trimester of pregnancy. We did not identify any statistically significant increased risk of orofacial clefts associated with the use of corticosteroids: cleft lip with or without cleft palate, prevalence odds ratio (OR) 1.05 (95% confidence interval [CI] 0.80-1.38]; cleft palate alone, prevalence OR 1.23 (95% CI 0.83-1.82). Odds ratios for risk of orofacial clefts by method of delivery (i.e., oral, inhalant, nasal spray, or dermatologic and other topicals) were consistent with the overall results of the study and did not display significant heterogeneity, although the OR for cleft lip with or without cleft palate associated with the use of dermatologic corticosteroids was 1.45 (95% CI 1.03-2.05).InterpretationOur results add to the safety information on a class of drugs commonly used during pregnancy. Our study did not show an increased risk of orofacial clefts with the use of corticosteroids during pregnancy. Indepth investigation of the pattern of association between orofacial clefts and the use of dermatologic corticosteroids during pregnancy indicated that this result did not signify a causal connection and likely arose from multiple statistical comparisons.

Dataset Information

Maternal occupational physical activity and risk for orofacial clefts.

Objectives

Methods

Results

Conclusions

Publications

Maternal occupational physical activity and risk for orofacial clefts.

Similar Datasets

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