Dataset Information

PD-L1 expression in EBV associated gastric cancer: a systematic review and meta-analysis.

ABSTRACT:

Objectives

The aim of this systematic review and meta-analysis is to the summarize the evidence on programmed cell death protein ligand 1 (PD-L1) in Epstein-Barr virus associated gastric cancer (EBVaGC) and to estimate the expression rate of PD-L1 among this subtype of Gastric Cancer (GC).

Materials and methods

For this study, PubMed^®, EMBASE^® and Web of Science^® databases were searched for articles published until 1st November 2021. A total of 43 eligible publications with a total of 11,327 patients were included analysis based on inclusion and exclusion criteria. A total of 41 publications present data for proportion estimation and 33 for comparison of PD-L1 between EBV positive and negative GC. DerSimonian-Laird random-effects model was used for meta-analysis.

Results

The analysis showed that in EBVaGC the pooled positivity rate for PD-L1 was 54.6% (p < 0.001), with a high heterogeneity between the included studies, which was associated with variation on positivity criteria for PD-L1 expression. Overall, the study reveals an increased association between PD-L1 and EBVaGC (OR = 6.36, 95% CI 3.91-10.3, p < 0.001). Furthermore, the study revealed that GC with lymphoid stroma (GCLS) is highly associated with EBV (OR = 17.4, 95% CI 6.83-44.1, p < 0.001), with a pooled EBV positivity rate of 52.9% (p < 0.001).

Conclusions

Patients with EBVaGC tend to show higher PD-L1 expression, which enhances EBV positivity as a promising marker for patient selection for immunotherapy targeted agents. A uniform criteria for PD-L1 positivity in tumor cells is needed, as well as further prospective studies to validate our findings and their prognostic significance.

SUBMITTER: Lima A

PROVIDER: S-EPMC8941030 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

PD-L1 expression in EBV associated gastric cancer: a systematic review and meta-analysis.

Lima Áurea Á Sousa Hugo H Medeiros Rui R Nobre Amanda A Machado Manuela M

Discover oncology 20220322 1

<h4>Objectives</h4>The aim of this systematic review and meta-analysis is to the summarize the evidence on programmed cell death protein ligand 1 (PD-L1) in Epstein-Barr virus associated gastric cancer (EBVaGC) and to estimate the expression rate of PD-L1 among this subtype of Gastric Cancer (GC).<h4>Materials and methods</h4>For this study, PubMed<sup>®</sup>, EMBASE<sup>®</sup> and Web of Science<sup>®</sup> databases were searched for articles published until 1st November 2021. A total of 43 ...[more]

PMID: 35318527

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Dataset Information

PD-L1 expression in EBV associated gastric cancer: a systematic review and meta-analysis.

Objectives

Materials and methods

Results

Conclusions

Publications

PD-L1 expression in EBV associated gastric cancer: a systematic review and meta-analysis.

Similar Datasets

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