Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling.
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ABSTRACT:
SUBMITTER: Qu C
PROVIDER: S-EPMC8942808 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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Full-length MAVS, a mitochondrial antiviral-signaling protein, inhibits hepatitis E virus replication, requiring JAK-STAT signaling.
Qu Changbo C Li Yang Y Li Yunlong Y Pan Yihang Y
Archives of virology 20220324 5
Hepatitis E virus (HEV) infection is the leading cause of acute hepatitis worldwide. The mitochondrial antiviral signaling protein (MAVS)-mediated interferon (IFN) response plays a pivotal role in hepatic antiviral immunity. However, little is known about the effect of overexpression of MAVS on HEV infection. Full-length MAVS (FL-MAVS) is the main form of MAVS that increases the production of IFNs. Here, we studied the effect of FL-MAVS on HEV infection. We found that overexpression of FL-MAVS p ...[more]
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