Ontology highlight
ABSTRACT:
SUBMITTER: Miller RM
PROVIDER: S-EPMC8976760 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Miller Rachel M RM Knoener Rachel A RA Benner Bayleigh E BE Frey Brian L BL Scalf Mark M Shortreed Michael R MR Sherer Nathan M NM Smith Lloyd M LM
Journal of proteome research 20220222 4
Human immunodeficiency virus type 1 (HIV-1) remains a deadly infectious disease despite existing antiretroviral therapies. A comprehensive understanding of the specific mechanisms of viral infectivity remains elusive and currently limits the development of new and effective therapies. Through in-depth proteomic analysis of HIV-1 virions, we discovered the novel post-translational modification of highly conserved residues within the viral matrix and capsid proteins to the dehydroamino acids, dehy ...[more]