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Two Novel Lytic Bacteriophages Infecting Enterococcus spp. Are Promising Candidates for Targeted Antibacterial Therapy.


ABSTRACT: The rapid emergence of antibiotic resistance is of major concern globally. Among the most worrying pathogenic bacteria are vancomycin-resistant enterococci. Phage therapy is a highly promising method for controlling enterococcal infections. In this study, we described two virulent tailed bacteriophages possessing lytic activity against Enterococcus faecalis and E. faecium isolates. The SSsP-1 bacteriophage belonged to the Saphexavirus genus of the Siphoviridae family, and the GVEsP-1 bacteriophage belonged to the Schiekvirus genus of Herelleviridae. The genomes of both viruses carried putative components of anti-CRISPR systems and did not contain known genes coding for antibiotic-resistance determinants and virulence factors. The conservative arrangement of protein-coding sequences in Saphexavirus and Schiekvirus genomes taken together with positive results of treating enterococcal peritonitis in an animal infection model imply the potential suitability of GVEsP-1 and SSsP-1 bacteriophages for clinical applications.

SUBMITTER: Tkachev PV 

PROVIDER: S-EPMC9030284 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Two Novel Lytic Bacteriophages Infecting <i>Enterococcus</i> spp. Are Promising Candidates for Targeted Antibacterial Therapy.

Tkachev Pavel V PV   Pchelin Ivan M IM   Azarov Daniil V DV   Gorshkov Andrey N AN   Shamova Olga V OV   Dmitriev Alexander V AV   Goncharov Artemiy E AE  

Viruses 20220416 4


The rapid emergence of antibiotic resistance is of major concern globally. Among the most worrying pathogenic bacteria are vancomycin-resistant enterococci. Phage therapy is a highly promising method for controlling enterococcal infections. In this study, we described two virulent tailed bacteriophages possessing lytic activity against <i>Enterococcus faecalis</i> and <i>E. faecium</i> isolates. The SSsP-1 bacteriophage belonged to the <i>Saphexavirus</i> genus of the <i>Siphoviridae</i> family,  ...[more]

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