Ontology highlight
ABSTRACT:
SUBMITTER: Hao WJ
PROVIDER: S-EPMC5489242 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
European journal of organic chemistry 20160329 11
A novel three-component bicyclization for the efficient synthesis of densely functionalized pyrazolo[3,4-<i>d</i>]thiazolo[3,2-<i>a</i>]pyrimidines has been established from readily accessible aryl aldehydes, α-thiocyanate ketones and pyrazol-5-amines. The reaction pathway involves nucleophilic addition/<i>5-exo-trig</i> /6-<i>endo-trig</i> bicyclization sequence, resulting in continuous multiple bond-forming events including C-N and C-C bonds to rapidly a molecular complexity. ...[more]