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Iridium-catalyzed ortho-selective carbon-hydrogen amidation of benzamides with sulfonyl azides in ionic liquid.

ABSTRACT: An efficient and convenient iridium(iii) catalyzed ortho-C-H bond amidation of weakly coordinating benzamides treated with readily available sulfonyl azides as the amino source has been described. In this transformation, ionic liquids represents an ideal reaction medium, giving rise to a broad range of amidation products under mild conditions in the open air. This protocol offers moderate to excellent chemical yields, exclusive regioselectivities, and good functional group tolerance.

SUBMITTER: Jiao LY

PROVIDER: S-EPMC9056170 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Iridium-catalyzed <i>ortho</i>-selective carbon-hydrogen amidation of benzamides with sulfonyl azides in ionic liquid.

Jiao Lin-Yu LY Ning Zi-Hui ZH Hong Qian Q Peng Xin-Hua XH Yin Xiao-Mei XM Liu Shanshan S Chen Huiyong H Li Zhuo Z Sun Ming M Ma Xiao-Xun XX

RSC advances 20200811 50

An efficient and convenient iridium(iii) catalyzed <i>ortho</i>-C-H bond amidation of weakly coordinating benzamides treated with readily available sulfonyl azides as the amino source has been described. In this transformation, ionic liquids represents an ideal reaction medium, giving rise to a broad range of amidation products under mild conditions in the open air. This protocol offers moderate to excellent chemical yields, exclusive regioselectivities, and good functional group tolerance. ...[more]

PMID: 35518216

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