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One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides.

ABSTRACT: One-pot three-component reactions using copper(i) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.

SUBMITTER: Reddy PR

PROVIDER: S-EPMC9077393 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides.

Reddy Parigi Raghavendar PR Cui Lianji L Ryu Jae-Sang JS

RSC advances 20180112 5

One-pot three-component reactions using copper(i) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields. ...[more]

PMID: 35541454

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