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The chemistry and biology of natural ribomimetics and related compounds.

ABSTRACT: Natural ribomimetics represent an important group of specialized metabolites with significant biological activities. Many of the activities, e.g., inhibition of seryl-tRNA synthetases, glycosidases, or ribosomes, are manifestations of their structural resemblance to ribose or related sugars, which play roles in the structural, physiological, and/or reproductive functions of living organisms. Recent studies on the biosynthesis and biological activities of some natural ribomimetics have expanded our understanding on how they are made in nature and why they have great potential as pharmaceutically relevant products. This review article highlights the discovery, biological activities, biosynthesis, and development of this intriguing class of natural products.

SUBMITTER: Tsunoda T 

PROVIDER: S-EPMC9092360 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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The chemistry and biology of natural ribomimetics and related compounds.

Tsunoda Takeshi T   Tanoeyadi Samuel S   Proteau Philip J PJ   Mahmud Taifo T  

RSC chemical biology 20220407 5

Natural ribomimetics represent an important group of specialized metabolites with significant biological activities. Many of the activities, <i>e.g.</i>, inhibition of seryl-tRNA synthetases, glycosidases, or ribosomes, are manifestations of their structural resemblance to ribose or related sugars, which play roles in the structural, physiological, and/or reproductive functions of living organisms. Recent studies on the biosynthesis and biological activities of some natural ribomimetics have exp  ...[more]

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