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Highly enantioselective copper-catalyzed propargylic amination to access N-tethered 1,6-enynes.

ABSTRACT: A highly enantioselective copper-catalyzed propargylic amination starting from benzylic allylic amines has been developed with a new chiral N,N,P ligand. A series of N-tethered 1,6-enynes were synthesized in good to excellent yields with excellent enantioselectivities. Utilization of transition metal-catalyzed cycloisomerization of 1,6-enynes provides several enantioselectively enriched chiral five-membered N-heterocycles efficiently.

SUBMITTER: Li SJ

PROVIDER: S-EPMC9127637 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Highly enantioselective copper-catalyzed propargylic amination to access <i>N</i>-tethered 1,6-enynes.

Li Si-Jia SJ Huang Jian J He Jin-Yu JY Zhang Rui-Jin RJ Qian Hao-Dong HD Dai Xue-Lin XL Kong Han-Han HH Xu Hao H

RSC advances 20201020 63

A highly enantioselective copper-catalyzed propargylic amination starting from benzylic allylic amines has been developed with a new chiral N,N,P ligand. A series of <i>N</i>-tethered 1,6-enynes were synthesized in good to excellent yields with excellent enantioselectivities. Utilization of transition metal-catalyzed cycloisomerization of 1,6-enynes provides several enantioselectively enriched chiral five-membered N-heterocycles efficiently. ...[more]

PMID: 35685332

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