Ontology highlight
ABSTRACT:
SUBMITTER: Bolton MJ
PROVIDER: S-EPMC9153083 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Bolton Marcus J MJ Ort Jordan T JT McBride Ryan R Swanson Nicholas J NJ Wilson Jo J Awofolaju Moses M Furey Colleen C Greenplate Allison R AR Drapeau Elizabeth M EM Pekosz Andrew A Paulson James C JC Hensley Scott E SE
Cell reports 20220501 9
Influenza viruses circulated at very low levels during the beginning of the COVID-19 pandemic, and population immunity against these viruses is low. An H3N2 strain (3C.2a1b.2a2) with a hemagglutinin (HA) that has several substitutions relative to the 2021-22 H3N2 vaccine strain is dominating the 2021-22 Northern Hemisphere influenza season. Here, we show that one of these substitutions eliminates a key glycosylation site on HA and alters sialic acid binding. Using glycan array profiling, we show ...[more]