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Potential Antigenic Mismatch of the H3N2 Component of the 2019 Southern Hemisphere Influenza Vaccine.

ABSTRACT: Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic as most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.

SUBMITTER: Gouma S

PROVIDER: S-EPMC7245157 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Potential Antigenic Mismatch of the H3N2 Component of the 2019 Southern Hemisphere Influenza Vaccine.

Gouma Sigrid S Weirick Madison M Hensley Scott E SE

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20200501 11

Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic as most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions. ...[more]

PMID: 31400756

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