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Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine.

ABSTRACT: The 2019-2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We find that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c2.A strains, including the currently circulating 3c2.A1b strain.

SUBMITTER: Gouma S 

PROVIDER: S-EPMC7229105 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine.

Gouma Sigrid S   Weirick Madison M   Hensley Scott E SE  

Nature communications 20200515 1

The 2019-2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We find that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c2.A strains, including the currently circulating 3c2.A1b strain. ...[more]

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