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Minimal residual disease negativity by next-generation flow in non-CR myeloma patients.

ABSTRACT: Next-generation flow (NGF) has detected minimal residual disease (MRD) in numerous myeloma patients who achieve a complete response (CR). However, when MRD is not detected via NGF in non-CR patients, its clinical meaning is uncertain. Here, we investigated the correlation between MRD findings on NGF and the response criteria, paying special attention to patients with discrepant results. We performed NGS analysis of IgH rearrangements on bone marrow samples from the non-CR patients with negative MRD on NGF. NGS detected residual abnormal clones in those patients, suggesting that NGF and NGS should be used in a complementary manner for MRD investigation.

SUBMITTER: Kim SM

PROVIDER: S-EPMC9175670 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Minimal residual disease negativity by next-generation flow in non-CR myeloma patients.

Kim Sung-Min SM Yang Naery Euphrasia NE Jeong Dajeong D Yun Jiwon J Ryu Sohee S Yoon Sung-Soo SS Ahn Yong-Oon YO Lee Dong Soon DS

EJHaem 20200922 2

Next-generation flow (NGF) has detected minimal residual disease (MRD) in numerous myeloma patients who achieve a complete response (CR). However, when MRD is not detected via NGF in non-CR patients, its clinical meaning is uncertain. Here, we investigated the correlation between MRD findings on NGF and the response criteria, paying special attention to patients with discrepant results. We performed NGS analysis of IgH rearrangements on bone marrow samples from the non-CR patients with negative ...[more]

PMID: 35844993

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