An impedimetric biosensor for COVID-19 serology test and modification of sensor performance via dielectrophoresis force.

ABSTRACT: Coronavirus disease 2019 (COVID-19) has caused significant global morbidity and mortality. The serology test that detects antibodies against the disease causative agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has often neglected value in supporting immunization policies and therapeutic decision-making. The ELISA-based antibody test is time-consuming and bulky. This work described a gold micro-interdigitated electrodes (IDE) biosensor for COVID antibody detection based on Electrochemical Impedance Spectroscopy (EIS) responses. The IDE architecture allows easy surface modification with the viral structure protein, Spike (S) protein, in the gap of the electrode digits to selectively capture anti-S antibodies in buffer solutions or human sera. Two strategies were emp

SUBMITTER: Zeng J 

PROVIDER: S-EPMC9186431 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature