Dataset Information

The watery eye quality of life (WEQOL) questionnaire: a patient-reported outcome measure for surgically amenable epiphora.

ABSTRACT:

Objective or purpose

To develop and test a patient-reported outcome measure for assessing health-related quality of life (HRQOL) in surgically amenable epiphora.

Design

Questionnaire development and validation study.

Participants

201 patients with a cause of epiphora amenable to surgical intervention, recruited across three independent centres.

Methods, intervention or testing

The watery eye quality of life (WEQOL) questionnaire was developed and refined according to defined psychometric standards. Both surgical and non-surgical participants completed WEQOL at baseline and follow-up (>3 months), along with the Lacrimal Symptom Questionnaire (Lac-Q), RAND Short Form Health Survey (SF-36) and Glasgow Benefit Inventory (GBI). Convergent validity of WEQOL was evaluated according to correlation (R > 0.40) with each of these additional tests. Responsiveness of WEQOL to intervention was evaluated according to patient-reported success. Test-retest reliability was assessed by the Bland-Altman method and intraclass correlation (ICC) in a subset of 64 participants at baseline.

Main outcome measures

WEQOL construct validity, responsiveness and test-retest reliability.

Results

WEQOL was moderately correlated (R > 0.4) with the Lac-Q and several subscales of the SF-36 (physical role limitation, social, emotional role limitation and emotional well-being). A stronger correlation was found between the change in WEQOL at follow-up and GBI (R = 0.61). An appropriate graded response was found with a significant change in WEQOL score being observed in patients reporting successful (-28%, p < 0.0001) and partially successful surgery (-6%, p = 0.04), but not in those reporting unsuccessful surgery (+2%, p = 0.9). High test-retest reliability was observed (ICC = 0.93).

Conclusions

The WEQOL questionnaire has been developed systematically according to modern psychometric standards and has been designed to evaluate the quality of life in patients with epiphora that is of a surgically amenable cause. In this study, it has demonstrated appropriate test-retest reliability, responsiveness and construct validity.

SUBMITTER: Schulz CB

PROVIDER: S-EPMC9232616 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

The watery eye quality of life (WEQOL) questionnaire: a patient-reported outcome measure for surgically amenable epiphora.

Schulz Christopher B CB Rainsbury Paul P Hoffman Jeremy J JJ Ah-Kye Laura L Yang Elizabeth E Malhotra Raman R Rogers Simon S Fayers Peter P Fayers Tessa T

Eye (London, England) 20210707 7

<h4>Objective or purpose</h4>To develop and test a patient-reported outcome measure for assessing health-related quality of life (HRQOL) in surgically amenable epiphora.<h4>Design</h4>Questionnaire development and validation study.<h4>Participants</h4>201 patients with a cause of epiphora amenable to surgical intervention, recruited across three independent centres.<h4>Methods, intervention or testing</h4>The watery eye quality of life (WEQOL) questionnaire was developed and refined according to ...[more]

PMID: 34234292

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Dataset Information

The watery eye quality of life (WEQOL) questionnaire: a patient-reported outcome measure for surgically amenable epiphora.

Objective or purpose

Design

Participants

Methods, intervention or testing

Main outcome measures

Results

Conclusions

Publications

The watery eye quality of life (WEQOL) questionnaire: a patient-reported outcome measure for surgically amenable epiphora.

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