Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8⁺ EMRA T Cells During Type 2 Diabetes.

ABSTRACT: Mitochondrial health and cellular metabolism can heavily influence the onset of senescence in T cells. CD8⁺ EMRA T cells exhibit mitochondrial dysfunction and alterations to oxidative phosphorylation, however, the metabolic properties of senescent CD8⁺ T cells from people living with type 2 diabetes (T2D) are not known. We show here that mitochondria from T2D CD8⁺ T cells had a higher oxidative capacity together with increased levels of mitochondrial reactive oxgen species (mtROS), compared to age-matched control cells. While fatty acid uptake was increased, fatty acid oxidation was impaired in T2D CD8⁺ EMRA T cells, which also showed an accumulation of lipid droplets and decreased AMPK activity. Increasing glucose and fatty acids in healthy CD8<

SUBMITTER: Callender LA 

PROVIDER: S-EPMC9261431 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature