Risk factors for the development of Spitz neoplasms.

ABSTRACT:

Background/objectives

The principal environmental risk factor for conventional nevi and melanomas is ultraviolet exposure. However, little is known about genetic or environmental risk factors for developing Spitz tumors. This study investigates risk factors associated with Spitz neoplasms.

Methods

Patients with Spitz tumors seen at Northwestern Memorial Hospital and Lurie Children's Hospital were surveyed with a 16-item questionnaire about environmental and inherited factors. Spitz tumor patients were compared to a pediatric control cohort from a similar clinical setting. This was supplemented with a meta-analysis of genetic and environmental causes of Spitz neoplasms.

Results

One hundred and six Spitz and 58 control surveys were obtained and no statistically signific

SUBMITTER: Benton S 

PROVIDER: S-EPMC9306590 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature