HFIP Mediates a Direct C-C Coupling between Michael Acceptors and Eschenmoser's salt.
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ABSTRACT: A direct C-C coupling process that merges Michael acceptors and Eschenmoser's salt is presented. Although reminiscent of the Morita-Baylis-Hillman reaction, this process requires no Lewis base catalyst. The underlying mechanism was unveiled by a combination of kinetic, isotopic labelling experiments as well as computational investigations, which showcased the critical role of HFIP as a superior mediator for proton-transfer events as well as the decisive role of the halide counterion.
SUBMITTER: Lemmerer M
PROVIDER: S-EPMC9306631 | biostudies-literature |
REPOSITORIES: biostudies-literature
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