Unknown

Dataset Information

0

Late-Stage Chemoenzymatic Installation of Hydroxy-Bearing Allyl Moiety on the Indole Ring of Tryptophan-Containing Peptides.


ABSTRACT: The late-stage functionalization of indole- and tryptophan-containing compounds with reactive moieties facilitates downstream diversification and leads to changes in their biological properties. Here, the synthesis of two hydroxy-bearing allyl pyrophosphates is described. A chemoenzymatic method is demonstrated which uses a promiscuous indole prenyltransferase enzyme to install a dual reactive hydroxy-bearing allyl moiety directly on the indole ring of tryptophan-containing peptides. This is the first report of late-stage indole modifications with this reactive group.

SUBMITTER: Mupparapu N 

PROVIDER: S-EPMC9314954 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC2969403 | biostudies-literature
| S-EPMC1222194 | biostudies-other
| S-EPMC7846737 | biostudies-literature
| S-EPMC8359131 | biostudies-literature
| S-EPMC6852662 | biostudies-literature
| S-EPMC2568979 | biostudies-literature
| S-EPMC10511408 | biostudies-literature
| S-EPMC6713104 | biostudies-literature
| S-EPMC7687270 | biostudies-literature
| S-EPMC9292901 | biostudies-literature