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Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections.

ABSTRACT: To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were significantly higher (cycle threshold [Ct], 21.76) in vaccinated compared to boostered (Ct, 23.14) individuals (P = .029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory was observed between double-vaccinated and boostered patients. Our results indicate that booster immunization results in a reduction in detectable viral loads without significantly changing viral load dynamics over time.

SUBMITTER: Dewald F

PROVIDER: S-EPMC9384619 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections.

Dewald Felix F Detmer Susanne S Pirkl Martin M Hellmich Martin M Heger Eva E Herrmann Maximilian M Lehmann Clara C Zweigner Janine J Klein Florian F

The Journal of infectious diseases 20221101 10

To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were significantly higher (cycle threshold [Ct], 21.76) in vaccinated compared to boostered (Ct, 23.14) individuals (P = .029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory wa ...[more]

PMID: 35906927

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