Ontology highlight
ABSTRACT:
SUBMITTER: Gygli SM
PROVIDER: S-EPMC9400913 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Gygli Sebastian M SM Loiseau Chloé C Jugheli Levan L Adamia Natia N Trauner Andrej A Reinhard Miriam M Ross Amanda A Borrell Sonia S Aspindzelashvili Rusudan R Maghradze Nino N Reither Klaus K Beisel Christian C Tukvadze Nestani N Avaliani Zaza Z Gagneux Sebastien S
Nature medicine 20210524 7
Multidrug-resistant tuberculosis (MDR-TB) accounts for one third of the annual deaths due to antimicrobial resistance<sup>1</sup>. Drug resistance-conferring mutations frequently cause fitness costs in bacteria<sup>2-5</sup>. Experimental work indicates that these drug resistance-related fitness costs might be mitigated by compensatory mutations<sup>6-10</sup>. However, the clinical relevance of compensatory evolution remains poorly understood. Here we show that, in the country of Georgia, durin ...[more]