Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves-Kulik M
PROVIDER: S-EPMC9405754 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Gonçalves-Kulik Mariane M Mier Pablo P Kastano Kristina K Cortés Juan J Bernadó Pau P Schmid Friederike F Andrade-Navarro Miguel A MA
Biomolecules 20220810 8
There is increasing evidence that many intrinsically disordered regions (IDRs) in proteins play key functional roles through interactions with other proteins or nucleic acids. These interactions often exhibit a context-dependent structural behavior. We hypothesize that low complexity regions (LCRs), often found within IDRs, could have a role in inducing local structure in IDRs. To test this, we predicted IDRs in the human proteome and analyzed their structures or those of homologous sequences in ...[more]