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Spongenolactones A-C, Bioactive 5,5,6,6,5-Pentacyclic Spongian Diterpenes from the Red Sea Sponge Spongia sp.


ABSTRACT: Three new 5,5,6,6,5-pentacyclic spongian diterpenes, spongenolactones A-C (1-3), were isolated from a Red Sea sponge Spongia sp. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and the absolute configurations of 1-3 were determined on the basis of comparison of the experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra. Compounds 1-3 are the first 5,5,6,6,5-pentacyclic spongian diterpenes bearing an β-hydroxy group at C-1. These metabolites were assayed for their cytotoxic, antibacterial, and anti-inflammatory activities. All three compounds were found to exert inhibitory activity against superoxide anion generation in fMLF/CB-stimulated human neutrophils. Furthermore, 1 showed a higher activity against the growth of Staphylococcus aureus in comparison to 2.

SUBMITTER: Tai CJ 

PROVIDER: S-EPMC9410434 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Spongenolactones A-C, Bioactive 5,5,6,6,5-Pentacyclic Spongian Diterpenes from the Red Sea Sponge <i>Spongia</i> sp.

Tai Chi-Jen CJ   Ahmed Atallah F AF   Chao Chih-Hua CH   Yen Chia-Hung CH   Hwang Tsong-Long TL   Chang Fang-Rong FR   Huang Yusheng M YM   Sheu Jyh-Horng JH  

Marine drugs 20220801 8


Three new 5,5,6,6,5-pentacyclic spongian diterpenes, spongenolactones A-C (<b>1</b>-<b>3</b>), were isolated from a Red Sea sponge <i>Spongia</i> sp. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and the absolute configurations of <b>1-</b><b>3</b> were determined on the basis of comparison of the experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra. Compounds <b>1</b>-<b>3</b> are the first 5,5,6,6,5-pentacyc  ...[more]

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