Ontology highlight
ABSTRACT:
SUBMITTER: Shintani-Domoto Y
PROVIDER: S-EPMC9565386 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Shintani-Domoto Yukako Y Sugiura Yuki Y Ogawa Makiko M Sugiyama Eiji E Abe Hiroyuki H Sakatani Takashi T Ohashi Ryuji R Ushiku Tetsuo T Fukayama Masashi M
PloS one 20221014 10
Serum amyloid A (SAA) is an acute phase protein, which undergoes structural changes and deposits in the extracellular matrix, causing organ damage. Systemic AA amyloidosis is a relatively common amyloid subtype among the more than 30 amyloid subtypes, but the mechanism of amyloid fibril formation remains unclear. In this study, we investigated the tissue distribution of SAA derived peptides in formalin-fixed paraffin embedded (FFPE) specimens of human myocardium with amyloidosis using matrix-ass ...[more]