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An Atlas of Thyroid Hormone Receptors' Target Genes in Mouse Tissues.

ABSTRACT: We gathered available RNA-seq and ChIP-seq data in a single database to better characterize the target genes of thyroid hormone receptors in several cell types. This database can serve as a resource to analyze the mode of action of thyroid hormone (T3). Additionally, it is an easy-to-use and convenient tool to obtain information on specific genes regarding T3 regulation or to extract large gene lists of interest according to the users' criteria. Overall, this atlas is a unique compilation of recent sequencing data focusing on T3, its receptors, modes of action, targets and roles, which may benefit researchers within the field. A preliminary analysis indicates extensive variations in the repertoire of target genes where transcription is upregulated by chromatin-bound nuclear receptors. Although it has a major influence, chromatin accessibility is not the only parameter that determines the cellular selectivity of the hormonal response.

SUBMITTER: Zekri Y

PROVIDER: S-EPMC9570117 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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An Atlas of Thyroid Hormone Receptors' Target Genes in Mouse Tissues.

Zekri Yanis Y Guyot Romain R Flamant Frédéric F

International journal of molecular sciences 20220928 19

We gathered available RNA-seq and ChIP-seq data in a single database to better characterize the target genes of thyroid hormone receptors in several cell types. This database can serve as a resource to analyze the mode of action of thyroid hormone (T3). Additionally, it is an easy-to-use and convenient tool to obtain information on specific genes regarding T3 regulation or to extract large gene lists of interest according to the users' criteria. Overall, this atlas is a unique compilation of rec ...[more]

PMID: 36232747

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