Atlas of target genes of thyroid hormone (TH) in mice
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA868404 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR21009113.fastq.gz | Fastqsanger.gz | |||
| SRR21009114.fastq.gz | Fastqsanger.gz | |||
| SRR21009115.fastq.gz | Fastqsanger.gz |
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Project description:We gathered in a single database available RNAseq and ChIPseq data to better characterize the target genes of the thyroid hormone receptors in several cell types. This database can serve as a resource to analyze the mode of action of the hormone. Also, it is an easy-handling convenient tool to obtain information on specific genes in regards to T3 regulation, or extract larger list of genes of interest based on the users’ criteria. Overall, this atlas is a unique compilation of recent sequencing data focusing on thyroid hormones, their receptors, mode of action, targets and roles which may profit researchers within the field. A preliminary analysis indicates extensive variations in the repertoire of target genes which transcription is upregulated by chromatin-bound nuclear receptor. Although it has a major influence, chromatin accessibility is not the only parameter that determines the cellular selectivity of hormonal response.
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Project description:To understand the role of TH target genes in BAT, we developped a murine transgenic model which expressed a tagged-form of the thyroid hormone receptor alpha (TRa1, tagged with GS which is a fusion between protein G and streptavidin) specifically in brown adipocytes. Combined with RNAseq data, it allowed to establish the direct target genes of thyroid hormones (TH) in brown adipocytes
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Project description:Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles. Keywords: cell cycle design,co-expression design,reference design,time series design Thyroid hormone (TH) controls remodeling of the pancreas. The micro array was carried out to identify changes in gene expression between the tadpole and frog pancreas. This is part 1, done on the 44K Xenopus platform. This dataset was used only for one pancreas experiment with several data points (control, 12h, 24h, 48h and frog). Each was made in triplicate. Samples in all 3 parts of the study received the same thyroid hormone levels.
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Project description:Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles. Keywords: co-expression design,development or differentiation design,reference design,time series design Overall design: Thyroid hormone (TH) controls remodeling of the pancreas. The microarray was carried out to identify changes in gene expression at different stages of development during metamorphosis.. This is part 3, done on the 22K Xenopus platform version 2. This dataset was from pancreas of Xenopus tadpoles (NF52, NF62, and NF66). Each was made in triplicate. Samples in all 3 parts of the study received the same thyroid hormone levels.
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